Scientific Research
Antiviral / Virology
- Microbial engineering for shikimate biosynthesis
- Shikimic acid biosynthesis in microorganisms: Current status and future direction
- Antiviral and Antioxidant Components from the Fruits of Illicium verum Hook.f. (Chinese Star Anise)
- Extraction of shikimic acid from water hyacinth (Eichhornia crassipes) using sonication: An approach towards waste valorization
- Shikimate Metabolic Pathway Engineering in Corynebacterium glutamicum
- Artificial cell factory design for shikimate production in Escherichia coli
- Shikimic acid in the light of current knowledge
- Inhibitory Activity of Illicium verum Extracts against Avian Viruses
- Antiviral activity of Illicium verum Hook. f. extracts against grouper iridovirus infection
- Star anise (Illicium verum): Chemical compounds, antiviral properties, and clinical relevance
- Shikimic Acid Promotes Oligodendrocyte Precursor Cell Differentiation and Accelerates Remyelination in Mice
- Production and Synthetic Modifications of Shikimic Acid
- Metabolic engineering strategies for enhanced shikimate biosynthesis: current scenario and future developments
- Novel comprehensive multidimensional liquid chromatography approach for elucidation of the microbosphere of shikimate-producing Escherichia coli SP1.1/pKD15.071 strain
- Preparation of crosslinked poly (acryloyloxyethyltrimethyl ammonium chloride) microsphere and its adsorption and mechanism towards shikimic acid
- Metabolic engineering of Corynebacterium glutamicum for shikimate overproduction by growth-arrested cell reaction
- Shikimic acid inhibits LPS-induced cellular pro-inflammatory cytokines and attenuates mechanical hyperalgesia in mice
- Studies on the production of shikimic acid using the aroK knockout strain of Bacillus megaterium
- Site-specific integration and constitutive expression of key genes into Escherichia coli chromosome increases shikimic acid yields
- Shikimic Acid Production in Escherichia coli: From Classical Metabolic Engineering Strategies to Omics Applied to Improve Its Production
- Generation of aroE overexpression mutant of Bacillus megaterium for the production of shikimic acid
- In Vitro Neuroprotective Effect of Shikimic Acid Against Hydrogen Peroxide-Induced Oxidative Stress
- Shikimic acid, a base compound for the formulation of swine/avian flu drug: statistical optimization, fed-batch and scale up studies along with its application as an antibacterial agent
- Synthesis and biological evaluation of oseltamivir analogues from shikimic acid
- Improvements of shikimic acid production in Escherichia coli with ideal metabolic modification in biosynthetic pathway--a review
- Production of shikimic acid from Escherichia coli through chemically inducible chromosomal evolution and cofactor metabolic engineering
- Illicium verum extract suppresses IFN-gamma-induced ICAM-1 expression via blockade of JAK/STAT pathway in HaCaT human keratinocytes
- Expanding horizons of shikimic acid. Recent progresses in production and its endless frontiers in application and market trends
- A natural isolate producing shikimic acid: isolation, identification, and culture condition optimization
- Illicium verum extract inhibits TNF-alpha- and IFN-gamma-induced expression of chemokines and cytokines in human keratinocytes
- A short overview on the medicinal chemistry of (-)-shikimic acid
- Synthesis of the anti-influenza agent (-)-oseltamivir free base and (-)-methyl 3-epi-shikimate
- Production of shikimic acid
- Metabolic engineering for the production of shikimic acid in an evolved Escherichia coli strain lacking the phosphoenolpyruvate: carbohydrate phosphotransferase system
- Efficient access to oseltamivir phosphate (Tamiflu) via the O-trimesylate of shikimic acid ethyl ester
- A short and practical synthesis of oseltamivir phosphate (Tamiflu) from (-)-shikimic acid
- Study on the sorption and isolation of shikimic acid by 717 anion exchange resin
- Immunomodulatory activity of shikimic acid and quercitin in comparison with oseltamivir (Tamiflu) in an in vitro model
- Anaphylaxis after Oseltamivir (Tamiflu) therapy in a patient with sensitization to star anise and celery-carrot-mugwort-spice syndrome
- Two new compounds and anti-HIV active constituents from Illicium verum
- Metabolic engineering for microbial production of shikimic acid
Immune System / Immunology
- Ameliorative effects of vitamins-loaded flavoured nanophytosomes fortified with star anise volatile oil against CsA-Induced liver and kidney injury in rats: Application in functional ice cream
- Shikimic Acid Regulates the NF-kappaB/MAPK Signaling Pathway and Gut Microbiota to Ameliorate DSS-Induced Ulcerative Colitis
- The Biological Activity of Illicium verum (Star Anise) on Lernaea cyprinacea-Infested Carassius auratus (Goldfish): In Vivo Study
- Bacillus H47 triggers Olea europaea metabolism activating DOXP and shikimate pathways simultaneously and modifying leaf extracts' antihypertensive activity
- Effects of Illicium verum Hook. f. (Chinese herb) enriched diet on growth performance, immune response and disease resistance in Catla catla [Hamilton] fingerlings against Aeromonashydrophila
- The shikimate pathway regulates programmed cell death
- Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3(+) Regulatory T Cells and Inhibition of Th2 Cytokines in Mice
- Shikimic acid inhibits LPS-induced cellular pro-inflammatory cytokines and attenuates mechanical hyperalgesia in mice
- Molecular characteristics of Illicium verum extractives to activate acquired immune response
- Cationic amphiphile with shikimic acid headgroup shows more systemic promise than its mannosyl analogue as DNA vaccine carrier in dendritic cell based genetic immunization
- Red clover coumarate 3'-hydroxylase (CYP98A44) is capable of hydroxylating p-coumaroyl-shikimate but not p-coumaroyl-malate: implications for the biosynthesis of phaselic acid
- Immunomodulatory activity of shikimic acid and quercitin in comparison with oseltamivir (Tamiflu) in an in vitro model
- Silencing of hydroxycinnamoyl-coenzyme A shikimate/quinate hydroxycinnamoyltransferase affects phenylpropanoid biosynthesis
COVID-19 / SARS-CoV-2
- Discovery of Potential Noncovalent Inhibitors of Dehydroquinate Dehydratase from Methicillin-Resistant <em>Staphylococcus aureus</em> through Computational-Driven Drug Design
- Essential oils block cellular entry of SARS-CoV-2 delta variant
- Identification of a promising inhibitor from Illicium verum (star anise) against the main protease of SARS-CoV-2: insights from the computational study
- Biosynthetic studies through feeding experiments in <em>Eclipta prostrata</em> (L.) L. hairy roots
- Anti-SARS-CoV-2 potential of Cissampelos pareira L. identified by connectivity map-based analysis and in vitro studies
- Towards Understanding COVID-19: Molecular Insights, Co-infections, Associated Disorders, and Aging
- NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism
- In Silico Studies Reveal Antiviral Effects of Traditional Indian Spices on COVID-19
Chemistry Data
Open Chemistry Data
Additional Research:
Antioxidant
- Shikimic acid (SA) inhibits neuro-inflammation and exerts neuroprotective effects in an LPS-induced in vitro and in vivo model
- Shikimic acid recovers diarrhea and its complications in SD rats fed lactose diet to induce diarrhea
- Altered profile of floral volatiles and lignin content by down-regulation of Caffeoyl Shikimate Esterase in Petunia
- Continuous-imprinted-layer nanofiber membrane with MXene-based precise-designed nanocages for high-accuracy recognition and separation of shikimic acid
- Extraction of shikimic acid from water hyacinth (Eichhornia crassipes) using sonication: An approach towards waste valorization
- Mangiterpenes A-C and 2',3'-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae
- Hypolipogenic Effect of Shikimic Acid Via Inhibition of MID1IP1 and Phosphorylation of AMPK/ACC
- Shikimic Acid Promotes Oligodendrocyte Precursor Cell Differentiation and Accelerates Remyelination in Mice
- Shikimic Acid Inhibits Osteoclastogenesis in Vivo and in Vitro by Blocking RANK/TRAF6 Association and Suppressing NF-kappaB and MAPK Signaling Pathways
- Enhanced biosynthesis of arbutin by engineering shikimate pathway in Pseudomonas chlororaphis P3
- Shikimic acid from Artemisia absinthium inhibits protein glycation in diabetic rats
- Biotechnological production of aromatic compounds of the extended shikimate pathway from renewable biomass
- Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid
- Shikimic acid inhibits LPS-induced cellular pro-inflammatory cytokines and attenuates mechanical hyperalgesia in mice
- Skin whitening capability of shikimic acid pathway compound
- In Vitro Neuroprotective Effect of Shikimic Acid Against Hydrogen Peroxide-Induced Oxidative Stress
- Protective effect of coconut water concentrate and its active component shikimic acid against hydroperoxide mediated oxidative stress through suppression of NF-kappaB and activation of Nrf2 pathway
- Identification of Novel Polyphenolic Inhibitors of Shikimate Dehydrogenase (AroE)
- Ameliorative effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis and their mechanisms in rats
- The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways
- Plants as biofactories: glyphosate-induced production of shikimic acid and phenolic antioxidants in wounded carrot tissue
- Anti-inflammatory effect of 3,4-oxo-isopropylidene-shikimic acid on acetic acid-induced colitis in rats
- Protective effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis induced by trinitrobenzenesulfonic acid in rats
- Expression balances of structural genes in shikimate and flavonoid biosynthesis cause a difference in proanthocyanidin accumulation in persimmon (Diospyros kaki Thunb.) fruit
- Immunomodulatory activity of shikimic acid and quercitin in comparison with oseltamivir (Tamiflu) in an in vitro model
- Characterization and isolation of some genes of the shikimate pathway in sensitive and resistant Centaurea jacea plants after ozone exposure
- Protective effect of 3,4-oxo-isopropylidene-shikimic acid on vascular endothelial cell injured by hydrogen peroxide
- Engineering plant shikimate pathway for production of tocotrienol and improving herbicide resistance
- Genotoxicity studies of quercetin and shikimate in vivo in the bone marrow of mice and gastric mucosal cells of rats
- Cytotoxicity studies of quercetin, shikimate, cyclohexanecarboxylate and ptaquiloside
Anti-inflammatory
- Synergism with Shikimic Acid Restores beta-Lactam Antibiotic Activity against Methicillin-Resistant Staphylococcus aureus
- Two New Sesquiterpenoids and a New Shikimic Acid Metabolite from Mangrove Sediment-Derived Fungus Roussoella sp. SCSIO 41427
- Shikimic acid (SA) inhibits neuro-inflammation and exerts neuroprotective effects in an LPS-induced in vitro and in vivo model
- Shikimic Acid Regulates the NF-kappaB/MAPK Signaling Pathway and Gut Microbiota to Ameliorate DSS-Induced Ulcerative Colitis
- Chondro-Protective Effects of Shikimic Acid on Osteoarthritis via Restoring Impaired Autophagy and Suppressing the MAPK/NF-kappaB Signaling Pathway
- Terpene-Shikimate conjugated meroterpenoids from the endophytic fungus Guignardia mangiferae
- Shikimic acid in the light of current knowledge
- Mangiterpenes A-C and 2',3'-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae
- Hypolipogenic Effect of Shikimic Acid Via Inhibition of MID1IP1 and Phosphorylation of AMPK/ACC
- Shikimic Acid Inhibits Osteoclastogenesis in Vivo and in Vitro by Blocking RANK/TRAF6 Association and Suppressing NF-kappaB and MAPK Signaling Pathways
- Enhanced biosynthesis of arbutin by engineering shikimate pathway in Pseudomonas chlororaphis P3
- Anti-inflammatory, analgesic and antioxidant activities of 3,4-oxo-isopropylidene-shikimic acid
- Shikimic acid inhibits LPS-induced cellular pro-inflammatory cytokines and attenuates mechanical hyperalgesia in mice
- An Overview of Compounds Derived from the Shikimate and Phenylpropanoid Pathways and Their Medicinal Importance
- Anti-inflammatory effect of 3,4-oxo-isopropylidene-shikimic acid on acetic acid-induced colitis in rats
- Simultaneous analysis of shikimate-derived secondary metabolites in Lithospermum erythrorhizon cell suspension cultures by high-performance liquid chromatography
Anticancer
- Illicium verum anticancer activity against MDA-MB-231 cell line
- Microbial engineering for shikimate biosynthesis
- Apoptosis induction in human hepatoma cell line HepG2 cells by trans- Anethole via activation of mitochondria-mediated apoptotic pathways
- Anticancer effect of Illicium verum (star anise fruit) against human breast cancer MCF-7 cell line
- Antioxidant associated chemoprophylaxis effect of natural spice and green vegetable on hepatotoxicity
- <em>Anisi Stellati Fructus</em>, a Significant Traditional Chinese Medicine (TCM) Herb and Its Bioactivity against Gastric Cancer
- Multistage Extraction of Star Anise and Black Pepper Derivatives for Antibacterial, Antioxidant, and Anticancer Activity
- <em>trans</em>-Anethole Abrogates Cell Proliferation and Induces Apoptosis through the Mitochondrial-Mediated Pathway in Human Osteosarcoma Cells
- Chemical Composition and in Vitro Cytotoxic Screening of Sixteen Commercial Essential Oils on Five Cancer Cell Lines
- Shikimic Acid Promotes Oligodendrocyte Precursor Cell Differentiation and Accelerates Remyelination in Mice
- (-)-Shikimic Acid as a Chiral Building Block for the Synthesis of New Cytotoxic 6-Aza-Analogues of Angucyclinones
- A new flavane acid from the fruits of Illicium verum
- Anethole suppressed cell survival and induced apoptosis in human breast cancer cells independent of estrogen receptor status
- New approach to the total synthesis of (-)-zeylenone from shikimic acid
- Synthesis and cytotoxicity of shikimate analogues. Structure:activity studies based on 1-crotonyloxymethyl-3R,4R,5R-trihydroxycyclohex-2-enone
- Shikimic acid complexes of platinum. Preparation, reactivity, and antitumor activity of (R,R-1,2-diaminocyclohexane) bis(shikimato) platinum(II). Evidence for a novel rearrangement involving platinum-carbon bond formation
Found in Formulas
Reported Therapeutic Roles
- Antiviral
- Antipyretic
- Antioxidant
- Anticoagulant
- Antithrombotic
- Anti-inflammatory
- Analgesic
- Anti-cancer
- Anti-tumor
- Antibacterial
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