Scientific Research
Antiviral / Virology
- Hesperidin, a Potential Antiviral Agent against SARS-CoV-2: The Influence of Citrus Consumption on COVID-19 Incidence and Severity in China
- Comparative metabolomics analysis of Citrus medica var. sarcodactylis Swingle and Limonia acidissima Linn. Fruits and leaves cultivated in Egypt in context to their antiviral effects
- Testicular protective effects of hesperidin against chemical and biological toxicants
- The First Records of the In Silico Antiviral and Antibacterial Actions of Molecules Detected in Extracts of Algerian Fir (Abies numidica De Lannoy) Using LC-MS/MS Analysis
- Drug repurposing: identification of SARS-CoV-2 potential inhibitors by virtual screening and pharmacokinetics strategies
- Eco-Technological Evaluation of Natural Phytochemicals Potential Drug Molecules Against Main Protease: A Machine Learning Algorithm
- Biosynthesis of Hesperetin, Homoeriodictyol, and Homohesperetin in a Transcriptomics-Driven Engineered Strain of Streptomyces albidoflavus
- Hesperetin blocks poxvirus replication with a low tendency to select for drug-resistant viral variants
- Flavonoids: A treasure house of prospective pharmacological potentials
- Effectiveness of Drug Repurposing and Natural Products Against SARS-CoV-2: A Comprehensive Review
- Latin American Plants against Microorganisms
- Influence of colour background on anti-viral activity against viral haemorrhagic septicaemia virus in zebrafish regulated by circadian rhythm signalling pathway
- Computational Approaches to Designing Antiviral Drugs against COVID-19: A Comprehensive Review
- Hesperitin attenuates alcoholic steatohepatitis by regulating TLR4/NF-κB signaling in mice
- Natural compounds as possible anti-SARS-CoV-2 therapeutic agents: an in-vitro and in-silico study
- Virtual screening indicates potential inhibitors of the P2X7 receptor
- An Insight into <em>Citrus medica</em> Linn.: A Systematic Review on Phytochemical Profile and Biological Activities
- Study on the mechanism of Shuganzhi Tablet against nonalcoholic fatty liver disease and lipid regulation effects of its main substances in vitro
- Preparation of Neohesperidin-Taro Starch Complex as a Novel Approach to Modulate the Physicochemical Properties, Structure and In Vitro Digestibility
- Preliminary exploration of method for screening efficacy markers compatibility in TCM prescriptions based on Q-markers: Anti-inflammatory activity of Dachaihu decoction as an example
- Crystal engineering of ionic cocrystals comprising Na/K salts of hesperetin with hesperetin molecules and solubility modulation
- Establishment of angiotensin-converting enzyme 2 and cluster of differentiation 147 dual target cell membrane chromatography based on SNAP-tag technology for screening anti severe acute respiratory syndrome coronavirus 2 active components
- Antimicrobial and Antiviral Compounds of Phlomis viscosa Poiret
- Effects of several flavonoids on human gut microbiota and its metabolism by <em>in vitro</em> simulated fermentation
- In silico prediction of potential inhibitors for SARS-CoV-2 Omicron variant using molecular docking and dynamics simulation-based drug repurposing
- CD4/CD8 Ratio Outcome According to the Class of the Third Active Drug in Antiretroviral Therapy Regimens: Results From the Quebec Human Immunodeficiency Virus Cohort Study
- Structure-Based Virtual Screening and Functional Validation of Potential Hit Molecules Targeting the SARS-CoV-2 Main Protease
- Identification of phytochemicals in Qingfei Paidu decoction for the treatment of coronavirus disease 2019 by targeting the virus-host interactome
- Polyphenolic promiscuity, inflammation-coupled selectivity: Whether PAINs filters mask an antiviral asset
- Targeting the DENV NS2B-NS3 protease with active antiviral phytocompounds: structure-based virtual screening, molecular docking and molecular dynamics simulation studies
- Hesperidin: A Potential Therapeutic Agent against COVID-19
- Molecular docking study of various <em>Enterovirus-A71</em> 3C protease proteins and their potential inhibitors
- In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease
- Simultaneous determination and pharmacokinetic study of five compounds from total extract of Clinopodium chinense in abnormal uterine bleeding rat plasma by UPLC-MS/MS
- Hesperetin from Root Extract of Clerodendrum petasites S. Moore Inhibits SARS-CoV-2 Spike Protein S1 Subunit-Induced NLRP3 Inflammasome in A549 Lung Cells via Modulation of the Akt/MAPK/AP-1 Pathway
- A potent virucidal activity of functionalized TiO(2) nanoparticles adsorbed with flavonoids against SARS-CoV-2
- Hesperidin hexosomal loaded nanodispersion: insights of its antimycobacterial, cytotoxic and anti-HCoV effects
- Virtual screening of Indonesian herbal compounds as COVID-19 supportive therapy: machine learning and pharmacophore modeling approaches
- Senna makki and other active phytochemicals: Myths and realities behind covid19 therapeutic interventions
- High-Resolution Magic-Angle Spinning NMR Spectroscopy for Evaluation of Cell Shielding by Virucidal Composites Based on Biogenic Silver Nanoparticles, Flexible Cellulose Nanofibers and Graphene Oxide
- Hesperetin and the PI3K/AKT pathway: Could their interaction play a role in the entry and replication of the SARS-CoV-2?
- Exploring the inhibitory potential of <em>Saussurea costus</em> and <em>Saussurea involucrata</em> phytoconstituents against the Spike glycoprotein receptor binding domain of SARS-CoV-2 Delta (B.1.617.2) variant and the main protease (M<sub>pro</sub>) as therapeutic candidates, using Molecular docking, DFT, and ADME/Tox studies
- Thymus capitatus flavonoids inhibit infection of Kaposi's sarcoma-associated herpesvirus
- Hesperidin identified from Citrus extracts potently inhibits HCV genotype 3a NS3 protease
- Molecular Docking and Molecular Dynamics Simulation of Fisetin, Galangin, Hesperetin, Hesperidin, Myricetin, and Naringenin against Polymerase of Dengue Virus
- A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19
- Exploring the Potential Pharmacological Mechanism of Hesperidin and Glucosyl Hesperidin against COVID-19 Based on Bioinformatics Analyses and Antiviral Assays
- Citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2
- Health-promoting and disease-mitigating potential of Verbascum thapsus L. (common mullein): A review
- A multi-targeted approach to identify potential flavonoids against three targets in the SARS-CoV-2 life cycle
- Hesperidin Reduces Memory Impairment Associated with Adult Rat Hippocampal Neurogenesis Triggered by Valproic Acid
- Plant-Derived Natural Non-Nucleoside Analog Inhibitors (NNAIs) against <em>RNA-Dependent RNA Polymerase</em> Complex (nsp7/nsp8/nsp12) of SARS-CoV-2
- A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV
- Molecular docking and dynamics studies on propolis sulabiroin-A as a potential inhibitor of SARS-CoV-2
- Hesperetin inhibits KSHV reactivation and is reversed by HIF1alpha overexpression
- Promising Natural Compounds against Flavivirus Proteases: Citrus Flavonoids Hesperetin and Hesperidin
- Citrus flavonoids as potential therapeutic agents: A review
- Network-Based Identification and Experimental Validation of Drug Candidates Toward SARS-CoV-2 <em>via</em> Targeting Virus-Host Interactome
- Potential effects of a flavonoid, hesperidin on SARS-CoV-2 disease
- Effectiveness of Natural Antioxidants against SARS-CoV-2? Insights from the <em>In-Silico</em> World
- Polyphenols and their potential role to fight viral diseases: An overview
- Combining SARS-CoV-2 Proofreading Exonuclease and RNA-Dependent RNA Polymerase Inhibitors as a Strategy to Combat COVID-19: A High-Throughput <em>in silico</em> Screening
- Empagliflozin and neohesperidin protect against methotrexate-induced renal toxicity via suppression of oxidative stress and inflammation in male rats
- Effects of Citrus Fruit Juices and Their Bioactive Components on Inflammation and Immunity: A Narrative Review
- Candidate Anti-COVID-19 Medicinal Plants from Ethiopia: A Review of Plants Traditionally Used to Treat Viral Diseases
- Flavonoids as Promising Antiviral Agents against SARS-CoV-2 Infection: A Mechanistic Review
- Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2
- Electron Donor-Acceptor Capacity of Selected Pharmaceuticals against COVID-19
- Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry
- Can nutraceuticals assist treatment and improve covid-19 symptoms?
- An in silico approach to target RNA-dependent RNA polymerase of COVID-19 with naturally occurring phytochemicals
- Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2
- Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2
- Evaluation of flavonoids as 2019-nCoV cell entry inhibitor through molecular docking and pharmacological analysis
- Herbal Medicines to Fight Against COVID-19: New Battle with an Old Weapon
- Immunomodulatory effect of Noni fruit and its isolates: insights into cell-mediated immune response and inhibition of LPS-induced THP-1 macrophage inflammation
- Discovering Potential RNA Dependent RNA Polymerase Inhibitors as Prospective Drugs Against COVID-19: An in silico Approach
- Potential Natural Products Against Respiratory Viruses: A Perspective to Develop Anti-COVID-19 Medicines
- Nutraceuticals in the Prevention of Viral Infections, including COVID-19, among the Pediatric Population: A Review of the Literature
- Ingredients such as trehalose and hesperidin taken as supplements or foods reverse alterations in human T cells, reducing asbestos exposure-induced antitumor immunity
- Structure-activity relationship (SAR) and molecular dynamics study of withaferin-A fragment derivatives as potential therapeutic lead against main protease (M<sup>pro</sup>) of SARS-CoV-2
- Neohesperidin alleviated pathological damage and immunological imbalance in rat myocardial ischemia-reperfusion injury via inactivation of JNK and NF-κB p65
- Campanula macrostachya: biological activity and identification of phenolics using a liquid chromatography electrospray ionization tandem mass spectrometry system
- Screening and identification of bioactive compounds from citrus against non-structural protein 3 protease of hepatitis C virus genotype 3a by fluorescence resonance energy transfer assay and mass spectrometry
- Depicting the inhibitory potential of polyphenols from <em>Isatis indigotica</em> root against the main protease of SARS CoV-2 using computational approaches
- Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action
- Antioxidative and therapeutic potential of selected Australian plants: A review
- Identification of saquinavir as a potent inhibitor of dimeric SARS-CoV2 main protease through MM/GBSA
- In silico identification of strong binders of the SARS-CoV-2 receptor-binding domain
- Secondary metabolites from spice and herbs as potential multitarget inhibitors of SARS-CoV-2 proteins
- Targeting the 3CLpro and RdRp of SARS-CoV-2 with phytochemicals from medicinal plants of the Andean Region: molecular docking and molecular dynamics simulations
- Molecular docking study of potential phytochemicals and their effects on the complex of SARS-CoV2 spike protein and human ACE2
- Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID-19: A review
- Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qing-Fei-Pai-Du decoction in the treatment of COVID-19
- Interferon gamma/interleukin-4 modulation, anti-inflammatory and antioxidant effects of hesperidin in complete Freund's adjuvant (CFA)-induced arthritis model of rats
- Drug repurposing using computational methods to identify therapeutic options for COVID-19
- Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits
- Roles of flavonoids against coronavirus infection
- Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA-dependent RNA polymerase (RdRp) inhibition: an in-silico analysis
- Recognition of Natural Products as Potential Inhibitors of COVID-19 Main Protease (Mpro): In-Silico Evidences
Immune System / Immunology
- Immunoregulatory role of hesperidin against ovalbumin (OVA)-induced bronchial asthma and depression in rats
- Rat Mucosal Immunity following an Intensive Chronic Training and an Exhausting Exercise: Effect of Hesperidin Supplementation
- Influence of Diets Enriched with Flavonoids (Cocoa and Hesperidin) on the Systemic Immunity of Intensively Trained and Exhausted Rats
- Ingredients such as trehalose and hesperidin taken as supplements or foods reverse alterations in human T cells, reducing asbestos exposure-induced antitumor immunity
- Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise
- Effects of hesperidin on the growth performance, antioxidant capacity, immune responses and disease resistance of red swamp crayfish (Procambarus clarkii)
- Hesperetin as an adjuvant augments protective anti-tumour immunity responses in B16F10 melanoma by stimulating cytotoxic CD8(+) T cells
- A hesperetin derivative plays a role in immunoregulatory effect on human macrophages
- Radioprotective effect of hesperetin against gamma-irradiation-induced DNA damage and immune dysfunction in murine splenocytes
- Bee Venom and Hesperidin Effectively Mitigate Complete Freund's Adjuvant-Induced Arthritis Via Immunomodulation and Enhancement of Antioxidant Defense System
- Hesperidin methyl chalcone alleviates spinal tuberculosis in New Zealand white rabbits by suppressing immune responses
- Effect of minor bioactive food substances - rutin and hesperidin in their separate and combined alimentary arrives on the immune system of rats and the activity of nuclear factor NF-kB liver cells
- Immunomodulatory potential of hesperetin and chrysin through the cellular and humoral response
- Influence of Hesperidin on the Systemic and Intestinal Rat Immune Response
- Hesperidin ameliorates immunological outcome and reduces neuroinflammation in the mouse model of multiple sclerosis
- Individual and combined effects of genistein and hesperidin on immunity and intestinal morphometry in lipopolysacharide-challenged broiler chickens
- Orange juice and hesperidin promote differential innate immune response in macrophages ex vivo
- Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans
- Hesperidin partially restores impaired immune and nutritional function in irradiated mice
- The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro
- Comparison between the specific immunity obtained with plain staphylococcic anatoxin and with anatoxin treated with phosphorylated hesperidin
COVID-19 / SARS-CoV-2
- Hesperidin, a Potential Antiviral Agent against SARS-CoV-2: The Influence of Citrus Consumption on COVID-19 Incidence and Severity in China
- The First Records of the In Silico Antiviral and Antibacterial Actions of Molecules Detected in Extracts of Algerian Fir (<em>Abies numidica</em> De Lannoy) Using LC-MS/MS Analysis
- Drug repurposing: identification of SARS-CoV-2 potential inhibitors by virtual screening and pharmacokinetics strategies
- Moringa oleifera and Its Biochemical Compounds: Potential Multi-targeted Therapeutic Agents Against COVID-19 and Associated Cancer Progression
- Effectiveness of Drug Repurposing and Natural Products Against SARS-CoV-2: A Comprehensive Review
- Computational Approaches to Designing Antiviral Drugs against COVID-19: A Comprehensive Review
- Natural compounds as possible anti-SARS-CoV-2 therapeutic agents: an in-vitro and in-silico study
- Hesperidin: Enrichment, forced degradation, and structural elucidation of potential degradation products using spectral techniques
- Identification of chemical constituents of Qingjin Yiqi granules and comparative study on pharmacokinetics of 23 main bioactive components in normal and Lung-Qi deficiency rats by UPLC-MS/MS method
- Coupling of physical extraction and mathematical filtration in spectrophotometric analysis of natural therapy essential for prophylaxis and treatment of COVID-19 infection - Comparative study along with greenness evaluation
- Simultaneous determination of multiple components in rat plasma by UHPLC-sMRM for pharmacokinetic studies after oral administration of Qingjin Yiqi Granules
- Current Update on Role of Hesperidin in Inflammatory Lung Diseases: Chemistry, Pharmacology, and Drug Delivery Approaches
- Bioinformatics-based investigation on the genetic influence between SARS-CoV-2 infections and idiopathic pulmonary fibrosis (IPF) diseases, and drug repurposing
- Identification of host genomic biomarkers from multiple transcriptomics datasets for diagnosis and therapies of SARS-CoV-2 infections
- Simultaneous determination of twenty-nine active compounds in <em>fuzhengjiedu granules</em> by HPLC-QQQ-MS/MS
- Establishment of angiotensin-converting enzyme 2 and cluster of differentiation 147 dual target cell membrane chromatography based on SNAP-tag technology for screening anti severe acute respiratory syndrome coronavirus 2 active components
- In silico prediction of potential inhibitors for SARS-CoV-2 Omicron variant using molecular docking and dynamics simulation-based drug repurposing
- Structure-Based Virtual Screening and Functional Validation of Potential Hit Molecules Targeting the SARS-CoV-2 Main Protease
- Neohesperidin and spike RBD interaction in omicron and its sub-variants: In silico, structural and simulation studies
- Study on Flavonoids and Bioactivity Features of Pericarp of <em>Citrus reticulata</em> "Chachi" at Different Harvest Periods
- Identification of phytochemicals in Qingfei Paidu decoction for the treatment of coronavirus disease 2019 by targeting the virus-host interactome
- Inhibition of the predicted allosteric site of the SARS-CoV-2 main protease through flavonoids
- Fourteen-Day Evolution of COVID-19 Symptoms during the Third Wave in Nonvaccinated Subjects and Effects of Hesperidin Therapy: A Randomized, Double-Blinded, Placebo-Controlled Study
- Homology Modeling and Molecular Dynamics-Driven Search for Natural Inhibitors That Universally Target Receptor-Binding Domain of Spike Glycoprotein in SARS-CoV-2 Variants
- Polyphenolic promiscuity, inflammation-coupled selectivity: Whether PAINs filters mask an antiviral asset
- Hesperidin: A Potential Therapeutic Agent against COVID-19
- In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease
- Hesperetin from Root Extract of Clerodendrum petasites S. Moore Inhibits SARS-CoV-2 Spike Protein S1 Subunit-Induced NLRP3 Inflammasome in A549 Lung Cells via Modulation of the Akt/MAPK/AP-1 Pathway
- Hesperetin as an anti-SARS-CoV-2 agent can inhibit COVID-19-associated cancer progression by suppressing intracellular signaling pathways
- A potent virucidal activity of functionalized TiO(2) nanoparticles adsorbed with flavonoids against SARS-CoV-2
- Virtual screening of Indonesian herbal compounds as COVID-19 supportive therapy: machine learning and pharmacophore modeling approaches
- Senna makki and other active phytochemicals: Myths and realities behind covid19 therapeutic interventions
- In silico identification of SARS-CoV-2 spike (S) protein-ACE2 complex inhibitors from eight Tecoma species and cultivars analyzed by LC-MS
- Hesperetin and the PI3K/AKT pathway: Could their interaction play a role in the entry and replication of the SARS-CoV-2?
- Exploring the inhibitory potential of Saussurea costus and Saussurea involucrata phytoconstituents against the Spike glycoprotein receptor binding domain of SARS-CoV-2 Delta (B.1.617.2) variant and the main protease (M(pro)) as therapeutic candidates, using Molecular docking, DFT, and ADME/Tox studies
- Multidimensional in silico strategy for identification of natural polyphenols-based SARS-CoV-2 main protease (M(pro)) inhibitors to unveil a hope against COVID-19
- Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors
- A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19
- Exploring the Potential Pharmacological Mechanism of Hesperidin and Glucosyl Hesperidin against COVID-19 Based on Bioinformatics Analyses and Antiviral Assays
- Citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2
- In silico prediction and structure-based multitargeted molecular docking analysis of selected bioactive compounds against mucormycosis
- A multi-targeted approach to identify potential flavonoids against three targets in the SARS-CoV-2 life cycle
- COVID-19: General Strategies for Herbal Therapies
- Plant-Derived Natural Non-Nucleoside Analog Inhibitors (NNAIs) against RNA-Dependent RNA Polymerase Complex (nsp7/nsp8/nsp12) of SARS-CoV-2
- A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV
- Molecular docking and dynamics studies on propolis sulabiroin-A as a potential inhibitor of SARS-CoV-2
- Targeting CoV-2 spike RBD and ACE-2 interaction with flavonoids of Anatolian propolis by in silico and in vitro studies in terms of possible COVID-19 therapeutics
- <em>In silico</em> study of potential anti-SARS cell entry phytoligands from <em>Phlomis aurea</em>: a promising avenue for prophylaxis
- Network-Based Identification and Experimental Validation of Drug Candidates Toward SARS-CoV-2 via Targeting Virus-Host Interactome
- Potential effects of a flavonoid, hesperidin on SARS-CoV-2 disease
- Effectiveness of Natural Antioxidants against SARS-CoV-2? Insights from the In-Silico World
- Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection
- Polyphenols and their potential role to fight viral diseases: An overview
- Combining SARS-CoV-2 Proofreading Exonuclease and RNA-Dependent RNA Polymerase Inhibitors as a Strategy to Combat COVID-19: A High-Throughput in silico Screening
- Candidate Anti-COVID-19 Medicinal Plants from Ethiopia: A Review of Plants Traditionally Used to Treat Viral Diseases
- Flavonoids as Promising Antiviral Agents against SARS-CoV-2 Infection: A Mechanistic Review
- Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2
- Electron Donor-Acceptor Capacity of Selected Pharmaceuticals against COVID-19
- Virtual screening, ADMET profiling, PASS prediction, and bioactivity studies of potential inhibitory roles of alkaloids, phytosterols, and flavonoids against COVID-19 main protease (M(pro))
- Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study
- Can nutraceuticals assist treatment and improve covid-19 symptoms?
- An in silico approach to target RNA-dependent RNA polymerase of COVID-19 with naturally occurring phytochemicals
- Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2
- Flavonoids as potential phytotherapeutics to combat cytokine storm in SARS-CoV-2
- Evaluation of flavonoids as 2019-nCoV cell entry inhibitor through molecular docking and pharmacological analysis
- Herbal Medicines to Fight Against COVID-19: New Battle with an Old Weapon
- Discovering Potential RNA Dependent RNA Polymerase Inhibitors as Prospective Drugs Against COVID-19: An in silico Approach
- Potential Natural Products Against Respiratory Viruses: A Perspective to Develop Anti-COVID-19 Medicines
- Nutraceuticals in the Prevention of Viral Infections, including COVID-19, among the Pediatric Population: A Review of the Literature
- Structure-activity relationship (SAR) and molecular dynamics study of withaferin-A fragment derivatives as potential therapeutic lead against main protease (M(pro)) of SARS-CoV-2
- Nasal Delivery of Hesperidin/Chitosan Nanoparticles Suppresses Cytokine Storm Syndrome in a Mouse Model of Acute Lung Injury
- Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections
- Exploring the treatment of COVID-19 with Yinqiao powder based on network pharmacology
- Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M(pro)) and Spike (S) Glycoprotein Inhibitors: A Molecular Docking Study
- A novel screening strategy of anti-SARS-CoV-2 drugs via blocking interaction between Spike RBD and ACE2
- Depicting the inhibitory potential of polyphenols from Isatis indigotica root against the main protease of SARS CoV-2 using computational approaches
- Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action
- Identification of saquinavir as a potent inhibitor of dimeric SARS-CoV2 main protease through MM/GBSA
- In silico identification of strong binders of the SARS-CoV-2 receptor-binding domain
- Secondary metabolites from spice and herbs as potential multitarget inhibitors of SARS-CoV-2 proteins
- Targeting the 3CLpro and RdRp of SARS-CoV-2 with phytochemicals from medicinal plants of the Andean Region: molecular docking and molecular dynamics simulations
- Molecular docking study of potential phytochemicals and their effects on the complex of SARS-CoV2 spike protein and human ACE2
- Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID-19: A review
- Structural analysis, virtual screening and molecular simulation to identify potential inhibitors targeting 2'-O-ribose methyltransferase of SARS-CoV-2 coronavirus
- Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qing-Fei-Pai-Du decoction in the treatment of COVID-19
- Predicted therapeutic targets for COVID-19 disease by inhibiting SARS-CoV-2 and its related receptors
- Drug repurposing using computational methods to identify therapeutic options for COVID-19
- Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits
- Roles of flavonoids against coronavirus infection
- Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA-dependent RNA polymerase (RdRp) inhibition: an in-silico analysis
- Recognition of Natural Products as Potential Inhibitors of COVID-19 Main Protease (Mpro): In-Silico Evidences
- Potential of Flavonoid-Inspired Phytomedicines against COVID-19
- Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection?
- An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study
- Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): In silico and experimental study
- Discovery of potential multi-target-directed ligands by targeting host-specific SARS-CoV-2 structurally conserved main protease
Chemistry Data
Open Chemistry Data
Additional Research:
Antioxidant
- A follow-up on the hesperetin issue in modelling the first electrochemical oxidation potential and antioxidant activity of flavonoids
- Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster
- Hesperidin and chlorogenic acid mitigate arsenic-induced oxidative stress via redox regulation, photosystems-related gene expression, and antioxidant efficiency in the chloroplasts of Zea mays
- Effect of hesperidin on growth, photosynthesis, antioxidant systems and uptake of cadmium, copper, chromium and zinc by Celosia argentea plants
- The role of hesperidin as a cardioprotective strategy against doxorubicin-induced cardiotoxicity: The antioxidant, anti-inflammatory, antiapoptotic, and cytoprotective potentials
- The protective effects of hesperidin as an antioxidant against quinolinic acid-induced toxicity on oligodendroglia cells: An in vitro study
- The Palliative and Antioxidant Effects of Hesperidin against Lead-Acetate-Induced Testicular Injury in Male Wistar Rats
- Nano-hesperetin ameliorates 6-hydroxydopamine-induced behavioral deficits and oxidative damage by up-regulating gene expression of antioxidant enzymes
- Involvement of Nrf2 Activation and NF-kB Pathway Inhibition in the Antioxidant and Anti-Inflammatory Effects of Hesperetin in Activated BV-2 Microglial Cells
- Optimization of DIC-Tripolium Ecofriendly Extraction Process: Recovery of Hesperidin from Orange Byproducts, Antioxidant and alpha-Amylase Inhibition of Extracts
- Hesperidin via maintenance of mitochondrial function and antioxidant activity protects lithium toxicity in rat heart isolated mitochondria
- Rutin and Hesperidin Revoke the Hepatotoxicity Induced by Paclitaxel in Male Wistar Rats via Their Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities
- Hesperetin and Capecitabine Abate 1,2 Dimethylhydrazine-Induced Colon Carcinogenesis in Wistar Rats via Suppressing Oxidative Stress and Enhancing Antioxidant, Anti-Inflammatory and Apoptotic Actions
- Antioxidant, Antiapoptotic, and Anti-Inflammatory Effects of Hesperetin in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury
- Rutin and Hesperidin Alleviate Paclitaxel-Induced Nephrocardiotoxicity in Wistar Rats via Suppressing the Oxidative Stress and Enhancing the Antioxidant Defense Mechanisms
- Nano-hesperetin attenuates ketamine-induced schizophrenia-like symptoms in mice: participation of antioxidant parameters
- Intensifying Effect of Instant Controlled Pressure Drop (DIC) Pre-Treatment on Hesperidin Recovery from Orange Byproducts: In Vitro Antioxidant and Antidiabetic Activities of the Extracts
- Impacts of hesperidin on whey protein functionality: Interacting mechanism, antioxidant capacity, and emulsion stabilizing effects
- Investigation of Changes in Spermatozoon Characteristics, Chromatin Structure, and Antioxidant/Oxidant Parameters after Freeze-Thawing of Hesperidin (Vitamin P) Doses Added to Ram Semen
- A Comparative Study of Hesperetin, Hesperidin and Hesperidin Glucoside: Antioxidant, Anti-Inflammatory, and Antibacterial Activities In Vitro
- Effects of hesperidin on anti-inflammatory and antioxidant response in healthy people: a meta-analysis and meta-regression
- Therapeutic role of hesperidin in collagen-induced rheumatoid arthritis through antiglycation and antioxidant activities
- Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
- Comparison Between Hesperidin, Coumarin, and Deferoxamine Iron Chelation and Antioxidant Activity Against Excessive Iron in the Iron Overloaded Mice
- Antioxidant and Antitumor Activities of Newly Synthesized Hesperetin Derivatives
- Exogenous hesperidin and chlorogenic acid alleviate oxidative damage induced by arsenic toxicity in Zea mays through regulating the water status, antioxidant capacity, redox balance and fatty acid composition
- Naringin and Hesperidin Counteract Diclofenac-Induced Hepatotoxicity in Male Wistar Rats via Their Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities
- A novel layered double hydroxide-hesperidin nanoparticles exert antidiabetic, antioxidant and anti-inflammatory effects in rats with diabetes
- Hesperidin and Naringin Improve Broiler Meat Fatty Acid Profile and Modulate the Expression of Genes Involved in Fatty Acid beta-oxidation and Antioxidant Defense in a Dose Dependent Manner
- 8-Week Supplementation of 2S-Hesperidin Modulates Antioxidant and Inflammatory Status after Exercise until Exhaustion in Amateur Cyclists
- Antioxidant and anti-inflammatory effects of hesperidin methyl chalcone in experimental ulcerative colitis
- Attenuation of sodium arsenite-induced cardiotoxicity and neurotoxicity with the antioxidant, anti-inflammatory, and antiapoptotic effects of hesperidin
- Yuzu and Hesperidin Ameliorate Blood-Brain Barrier Disruption during Hypoxia via Antioxidant Activity
- Interferon gamma/interleukin-4 modulation, anti-inflammatory and antioxidant effects of hesperidin in complete Freund's adjuvant (CFA)-induced arthritis model of rats
- Enhanced antioxidant, anti-inflammatory and alpha-glucosidase inhibitory activities of citrus hesperidin by acid-catalyzed hydrolysis
- Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders
- Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats
- Hesperetin nanoparticles attenuate anxiogenic-like behavior and cerebral oxidative stress through the upregulation of antioxidant enzyme expression in experimental dementia of Alzheimer's type
- Effects of hesperidin on the growth performance, antioxidant capacity, immune responses and disease resistance of red swamp crayfish (Procambarus clarkii)
- Hesperidin improves motor disability in rat spinal cord injury through anti-inflammatory and antioxidant mechanism via Nrf-2/HO-1 pathway
- Acute Effects of Hesperidin in Oxidant/Antioxidant State Markers and Performance in Amateur Cyclists
- Cortico-hippocampal memory enhancing activity of hesperetin on scopolamine-induced amnesia in mice: role of antioxidant defense system, cholinergic neurotransmission and expression of BDNF
- Enhanced water solubility, antioxidant activity, and oral absorption of hesperetin by D-alpha-tocopheryl polyethylene glycol 1000 succinate and phosphatidylcholine
- Hesperidin regresses cardiac hypertrophy by virtue of PPAR-gamma agonistic, anti-inflammatory, antiapoptotic, and antioxidant properties
- Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro
- Bee Venom and Hesperidin Effectively Mitigate Complete Freund's Adjuvant-Induced Arthritis Via Immunomodulation and Enhancement of Antioxidant Defense System
- Antioxidant status, meat oxidative stability and quality characteristics of lambs fed with hesperidin, naringin or alpha-tocopheryl acetate supplemented diets
- Preventive effect of hesperidin modulates inflammatory responses and antioxidant status following acute myocardial infarction through the expression of PPAR-gamma and Bcl-2 in model mice
- Antihyperglycemic effect of hesperetin, a citrus flavonoid, extenuates hyperglycemia and exploring the potential role in antioxidant and antihyperlipidemic in streptozotocin-induced diabetic rats
- Enhancement of the water solubility and antioxidant activity of hesperidin by chitooligosaccharide
- Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats
- A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury
- Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice
- Characterization of the antioxidant activity of aglycone and glycosylated derivatives of hesperetin: an in vitro and in vivo study
- Hesperidin, A Popular Antioxidant Inhibits Melanogenesis via Erk1/2 Mediated MITF Degradation
- Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models
- Hesperidin and rutin, antioxidant citrus flavonoids, attenuate cisplatin-induced nephrotoxicity in rats
- Prunin- and hesperetin glucoside-alkyl (C4-C18) esters interaction with Jurkat cells plasma membrane: consequences on membrane physical properties and antioxidant capacity
- In vitro scavenger and antioxidant properties of hesperidin and neohesperidin dihydrochalcone
- Hesperidin-mediated expression of Nrf2 and upregulation of antioxidant status in senescent rat heart
- Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach
- Antioxidant capacity of hesperidin from citrus peel using electron spin resonance and cytotoxic activity against human carcinoma cell lines
- Hesperidin, a flavanone glycoside, on lipid peroxidation and antioxidant status in experimental myocardial ischemic rats
- Synthesis, characterization, DNA binding properties, fluorescence studies and antioxidant activity of transition metal complexes with hesperetin-2-hydroxy benzoyl hydrazone
- Hesperidin attenuates benzo[alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant/antioxidant balance
- Synthesis, characterization, DNA binding properties and antioxidant activity of Ln(III) complexes with hesperetin-4-one-(benzoyl) hydrazone
- Evaluation of antioxidant activity of hesperidin and its protective effect on H2O2 induced oxidative damage on pBR322 DNA and RBC cellular membrane
- The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin
- Hesperidin, an antioxidant flavonoid, prevents acrylonitrile-induced oxidative stress in rat brain
- Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice
- Effect of adding extracted hesperetin, naringenin and pectin on egg cholesterol, serum traits and antioxidant activity in laying hens
- Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention
- Antioxidant properties of hesperidin in nicotine-induced lung toxicity
- Effect of hesperidin on matrix metalloproteinases and antioxidant status during nicotine-induced toxicity
- Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin
- Antioxidant activity of the flavonoid hesperidin in chemical and biological systems
- Hesperetin: a potent antioxidant against peroxynitrite
Anti-inflammatory
- The role of hesperidin as a cardioprotective strategy against doxorubicin-induced cardiotoxicity: The antioxidant, anti-inflammatory, antiapoptotic, and cytoprotective potentials
- Involvement of Nrf2 Activation and NF-kB Pathway Inhibition in the Antioxidant and Anti-Inflammatory Effects of Hesperetin in Activated BV-2 Microglial Cells
- Rutin and Hesperidin Revoke the Hepatotoxicity Induced by Paclitaxel in Male Wistar Rats via Their Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities
- Hesperetin and Capecitabine Abate 1,2 Dimethylhydrazine-Induced Colon Carcinogenesis in Wistar Rats via Suppressing Oxidative Stress and Enhancing Antioxidant, Anti-Inflammatory and Apoptotic Actions
- Antioxidant, Antiapoptotic, and Anti-Inflammatory Effects of Hesperetin in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury
- Solid lipid nanoparticles (SLNs), the potential novel vehicle for enhanced in vivo efficacy of hesperidin as an anti-inflammatory agent
- A Comparative Study of Hesperetin, Hesperidin and Hesperidin Glucoside: Antioxidant, Anti-Inflammatory, and Antibacterial Activities In Vitro
- Effects of hesperidin on anti-inflammatory and antioxidant response in healthy people: a meta-analysis and meta-regression
- Electrospinning of antibacterial and anti-inflammatory Ag@hesperidin core-shell nanoparticles into nanofibers used for promoting infected wound healing
- Anti-inflammatory and anti-aggregating effects of rangpur in the first trimester of growth: ultra-performance liquid chromatography-electrospray mass spectrometry profile and quantification of hesperidin
- In Vitro and In Vivo Studies Reveal that Hesperetin-7-O-glucoside, a Naturally Occurring Monoglucoside, Exhibits Strong Anti-inflammatory Capacity
- Hesperetin Exhibits Anti-Inflammatory Effects on Chondrocytes via the AMPK Pathway to Attenuate Anterior Cruciate Ligament Transection-Induced Osteoarthritis
- Naringin and Hesperidin Counteract Diclofenac-Induced Hepatotoxicity in Male Wistar Rats via Their Antioxidant, Anti-Inflammatory, and Antiapoptotic Activities
- A novel layered double hydroxide-hesperidin nanoparticles exert antidiabetic, antioxidant and anti-inflammatory effects in rats with diabetes
- Antioxidant and anti-inflammatory effects of hesperidin methyl chalcone in experimental ulcerative colitis
- Kirenol, darutoside and hesperidin contribute to the anti-inflammatory and analgesic activities of Siegesbeckia pubescens makino by inhibiting COX-2 expression and inflammatory cell infiltration
- Attenuation of sodium arsenite-induced cardiotoxicity and neurotoxicity with the antioxidant, anti-inflammatory, and antiapoptotic effects of hesperidin
- Interferon gamma/interleukin-4 modulation, anti-inflammatory and antioxidant effects of hesperidin in complete Freund's adjuvant (CFA)-induced arthritis model of rats
- Enhanced antioxidant, anti-inflammatory and alpha-glucosidase inhibitory activities of citrus hesperidin by acid-catalyzed hydrolysis
- Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders
- Hesperidin Loaded on Gold Nanoparticles as a Drug Delivery System for a Successful Biocompatible, Anti-Cancer, Anti-Inflammatory and Phagocytosis Inducer Model
- Hesperetin conjugated PEGylated gold nanoparticles exploring the potential role in anti-inflammation and anti-proliferation during diethylnitrosamine-induced hepatocarcinogenesis in rats
- Hesperidin improves motor disability in rat spinal cord injury through anti-inflammatory and antioxidant mechanism via Nrf-2/HO-1 pathway
- Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-O-Amide Hesperetin Derivatives
- Hesperidin regresses cardiac hypertrophy by virtue of PPAR-gamma agonistic, anti-inflammatory, antiapoptotic, and antioxidant properties
- Immunohistochemical examination of anti-inflammatory and anti-apoptotic effects of hesperetin on trinitrobenzene sulfonic acid induced colitis in rats
- Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair
- The anti-inflammatory effect of hesperetin on lung damage induced by paraquat in rats
- Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives
- Metabolism of Phenolic Compounds in LPS-stimulated Raw264.7 Cells Can Impact Their Anti-inflammatory efficacy: Indication of Hesperetin
- Hesperidin attenuates influenza A virus (H1N1) induced lung injury in rats through its anti-inflammatory effect
- Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial
- Design, synthesis and biological evaluation of hesperetin derivatives as potent anti-inflammatory agent
- Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus
- Hesperidin alleviates rat postoperative ileus through anti-inflammation and stimulation of Ca(2+)-dependent myosin phosphorylation
- Hesperetin derivatives: Synthesis and anti-inflammatory activity
- Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models
- Protective effect of hesperetin in rat model of partial sciatic nerve ligation induced painful neuropathic pain: an evidence of anti-inflammatory and anti-oxidative activity
- Hesperidin metabolite hesperetin-7-O-glucuronide, but not hesperetin-3'-O-glucuronide, exerts hypotensive, vasodilatory, and anti-inflammatory activities
- Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach
- Antiinflammatory effects of traditional Korean medicine, JinPi-tang and its active ingredient, hesperidin in HaCaT cells
- Simultaneous determination of liquiritin, hesperidin, and glycyrrhizin by HPLC-photodiode array detection and the anti-inflammatory effect of Pyungwi-san
- Evaluation of antioxidative and anti-inflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation
- Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat
- Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS
- Biological effects of hesperidin, a citrus flavonoid. (Note I): antiinflammatory and analgesic activity
- Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice
Anticancer
- Comparative evaluation of hesperetin-loaded graphene oxide nanosheets (Hsp-GO) as a drug delivery system for colon cancer: synthesis and anticancer efficiency assessment
- Recent Progress in the Hesperetin Delivery Regimes: Significance of Pleiotropic Actions and Synergistic Anticancer Efficacy
- [Retracted] Hesperidin exhibits in vitro and in vivo antitumor effects in human osteosarcoma MG-63 cells and xenograft mice models via inhibition of cell migration and invasion, cell cycle arrest and induction of mitochondrial-mediated apoptosis
- Hesperidin Inhibits the p53-MDMXInteraction-Induced Apoptosis of Non-Small-Cell Lung Cancer and Enhances the Antitumor Effect of Carboplatin
- Hesperetin inhibits Eca-109 cell proliferation and invasion by suppressing the PI3K/AKT signaling pathway and synergistically enhances the anti-tumor effect of 5-fluorouracil on esophageal cancer in vitro and in vivo
- Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects
- Antioxidant and Antitumor Activities of Newly Synthesized Hesperetin Derivatives
- Anticancer Activities of Hesperidin via Suppression of Up-Regulated Programmed Death-Ligand 1 Expression in Oral Cancer Cells
- A mechanistic review of the anticancer potential of hesperidin, a natural flavonoid from citrus fruits
- Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system
- Ingredients such as trehalose and hesperidin taken as supplements or foods reverse alterations in human T cells, reducing asbestos exposure-induced antitumor immunity
- Hesperidin induces anticancer effects on human prostate cancer cells via ROS-mediated necrosis like cell death
- Hesperidin Loaded on Gold Nanoparticles as a Drug Delivery System for a Successful Biocompatible, Anti-Cancer, Anti-Inflammatory and Phagocytosis Inducer Model
- Targeting MDR-1 gene expression, BAX/BCL2, caspase-3, and Ki-67 by nanoencapsulated imatinib and hesperidin to enhance anticancer activity and ameliorate cardiotoxicity
- Combined administration of naringenin and hesperetin with optimal ratio maximizes the anti-cancer effect in human pancreatic cancer via down regulation of FAK and p38 signaling pathway
- Combination of hesperetin and platinum enhances anticancer effect on lung adenocarcinoma
- Comparative evaluation of hesperetin loaded nanoparticles for anticancer activity against C6 glioma cancer cells
- Hesperidin exhibits in vitro and in vivo antitumor effects in human osteosarcoma MG-63 cells and xenograft mice models via inhibition of cell migration and invasion, cell cycle arrest and induction of mitochondrial-mediated apoptosis
- Hesperidin, piperine and bee venom synergistically potentiate the anticancer effect of tamoxifen against breast cancer cells
- Chitosan-based nano-formulation enhances the anticancer efficacy of hesperetin
- Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity
- Evaluation of Antitumor Activity of Hesperetin-Loaded Nanoparticles Against DMBA-Induced Oral Carcinogenesis Based on Tissue Autofluorescence Spectroscopy and Multivariate Analysis
- Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice
Found in Formulas
Reported Therapeutic Roles
- Antiviral
- Antimicrobial
- Antioxidant
- Anti-inflammatory
- Anti-ageing
- Anticarcinogenic
- Anti-cancer
- Anti-tumor
- Antihypertensive
- Antidiabetic
- Hepatoprotective
- Anti-atherosclerotic
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