Scientific Research
Antiviral / Virology
- Cyanovirin-N Binding to N-Acetyl-d-glucosamine Requires Carbohydrate-Binding Sites on Two Different Protomers
- Corrigendum to "Structural and functional analysis of Cyanovirin-N homologs: Carbohydrate binding affinities and antiviral potential of cyanobacterial peptides" [J. Mol. Graph. Model. 129 (June 2024), 108718]
- Structural and functional analysis of Cyanovirin-N homologs: Carbohydrate binding affinities and antiviral potential of cyanobacterial peptides
- Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2
- Structural Insight into the Binding of Cyanovirin-N with the Spike Glycoprotein, M(pro) and PL(pro) of SARS-CoV-2: Protein-Protein Interactions, Dynamics Simulations and Free Energy Calculations
- Cyanovirin-N Binds Viral Envelope Proteins at the Low-Affinity Carbohydrate Binding Site without Direct Virus Neutralization Ability
- Design of fusion protein for efficient preparation of cyanovirin-n and rapid enrichment of pseudorabies virus
- Development of a Graphene-Based Biosensor for Detecting Recombinant Cyanovirin-N
- Genomic screening and molecular dynamics simulations of cyanovirin-N homologs from cyanobacteria phylum
- Preparation of a monoPEGylated derivative of cyanovirin-N and its virucidal effect on acyclovir-resistant strains of herpes simplex virus type 1
- Optimizing expression of antiviral cyanovirin-N homology gene using response surface methodology and protein structure prediction
- Structure and Glycan Binding of a New Cyanovirin-N Homolog
- A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity
- Cyanovirin-N produced in rice endosperm offers effective pre-exposure prophylaxis against HIV-1BaL infection in vitro
- Sensitivity of transmitted and founder human immunodeficiency virus type 1 envelopes to carbohydrate-binding agents griffithsin, cyanovirin-N and Galanthus nivalis agglutinin
- Preparation of monoPEGylated Cyanovirin-N's derivative and its anti-influenza A virus bioactivity in vitro and in vivo
- Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV
- A flexible docking scheme efficiently captures the energetics of glycan-cyanovirin binding
- Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses
- The antiviral lectin cyanovirin-N: probing multivalency and glycan recognition through experimental and computational approaches
- Chimeric Cyanovirin-MPER recombinantly engineered proteins cause cell-free virolysis of HIV-1
- Transformation of Althaea officinalis L. by Agrobacterium rhizogenes for the production of transgenic roots expressing the anti-HIV microbicide cyanovirin-N
- Fluorinated carbohydrates as lectin ligands: dissecting glycan-cyanovirin interactions by using 19F NMR spectroscopy
- Carbohydrate recognition by the antiviral lectin cyanovirin-N
- Rational and computational design of stabilized variants of cyanovirin-N that retain affinity and specificity for glycan ligands
- Incorporation of the HIV-1 microbicide cyanovirin-N in a food product
- Designed oligomers of cyanovirin-N show enhanced HIV neutralization
- Multivalent glyconanoparticles with enhanced affinity to the anti-viral lectin Cyanovirin-N
- Purification of Cyanovirin-N with antiviral activity and preparation as well as modification of its polyclonal antibody
- NMR solution structure of a cyanovirin homolog from wheat head blight fungus
- Optimization of the expression of the HIV fusion inhibitor cyanovirin-N from the tobacco plastid genome
- Antiviral activity of recombinant cyanovirin-N against HSV-1
- The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites
- Expression, purification and activity determination of cyanovirin-N
- Microvirin, a novel alpha(1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile
- Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin
- The antiviral protein cyanovirin-N: the current state of its production and applications
- Anti-HIV activity of defective cyanovirin-N mutants is restored by dimerization
- Solution and crystal molecular dynamics simulation study of m4-cyanovirin-N mutants complexed with di-mannose
- A sugar binding protein cyanovirin-N blocks herpes simplex virus type-1 entry and cell fusion
- A designed chimeric cyanovirin-N homolog lectin: structure and molecular basis of sucrose binding
- Soluble cytoplasmic expression, rapid purification, and characterization of cyanovirin-N as a His-SUMO fusion
- Multivalent interactions with gp120 are required for the anti-HIV activity of Cyanovirin
- Cyanovirin-N potently inhibits human immunodeficiency virus type 1 infection in cellular and cervical explant models
- Solution and crystal structures of a sugar binding site mutant of cyanovirin-N: no evidence of domain swapping
- Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N
- Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent
- Conformational gating of dimannose binding to the antiviral protein cyanovirin revealed from the crystal structure at 1.35 A resolution
- The evolutionarily conserved family of cyanovirin-N homologs: structures and carbohydrate specificity
- Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor
- PEGylation of cyanovirin-N, an entry inhibitor of HIV
- High-mannose-specific deglycosylation of HIV-1 gp120 induced by resistance to cyanovirin-N and the impact on antibody neutralization
- A monovalent mutant of cyanovirin-N provides insight into the role of multiple interactions with gp120 for antiviral activity
- Dissecting carbohydrate-Cyanovirin-N binding by structure-guided mutagenesis: functional implications for viral entry inhibition
- Engineered vaginal lactobacillus strain for mucosal delivery of the human immunodeficiency virus inhibitor cyanovirin-N
- Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes
- Computational study of the dynamics of mannose disaccharides free in solution and bound to the potent anti-HIV virucidal protein cyanovirin
- Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans
- Transgenic plant production of Cyanovirin-N, an HIV microbicide
- The anti-HIV cyanovirin-N domain is evolutionarily conserved and occurs as a protein module in eukaryotes
- Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A
- Expression, purification, and characterization of recombinant cyanovirin-N for vaginal anti-HIV microbicide development
- The highly specific carbohydrate-binding protein cyanovirin-N: structure, anti-HIV/Ebola activity and possibilities for therapy
- Atomic mapping of the interactions between the antiviral agent cyanovirin-N and oligomannosides by saturation-transfer difference NMR
- Development of a fluorescent microplate assay for determining cyanovirin-N levels in plasma
- In vitro evaluation of cyanovirin-N antiviral activity, by use of lentiviral vectors pseudotyped with filovirus envelope glycoproteins
- Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models
- Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaques
- Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin
- Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus
- Cyanovirin-N: a sugar-binding antiviral protein with a new twist
- Human immunodeficiency virus envelope (gp120) binding to DC-SIGN and primary dendritic cells is carbohydrate dependent but does not involve 2G12 or cyanovirin binding sites: implications for structural analyses of gp120-DC-SIGN binding
- Functional homologs of cyanovirin-N amenable to mass production in prokaryotic and eukaryotic hosts
- Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides
- Potent inhibition of HIV-1 fusion by cyanovirin-N requires only a single high affinity carbohydrate binding site: characterization of low affinity carbohydrate binding site knockout mutants
- The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures
- High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41
- Discovery of a stable dimeric mutant of cyanovirin-N (CV-N) from a T7 phage-displayed CV-N mutant library
- Engineering an obligate domain-swapped dimer of cyanovirin-N with enhanced anti-HIV activity
- Design and initial characterization of a circular permuted variant of the potent HIV-inactivating protein cyanovirin-N
- Solution structure of a cyanovirin-N:Man alpha 1-2Man alpha complex: structural basis for high-affinity carbohydrate-mediated binding to gp120
- Rapid validation of the overall structure of an internal domain-swapped mutant of the anti-HIV protein cyanovirin-N using residual dipolar couplings
- The potent anti-HIV protein cyanovirin-N contains two novel carbohydrate binding sites that selectively bind to Man(8) D1D3 and Man(9) with nanomolar affinity: implications for binding to the HIV envelope protein gp120
- 1H, 13C, 15N resonance assignments and fold verification of a circular permuted variant of the potent HIV-inactivating protein cyanovirin-N
- Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific manner
- Selective interactions of the human immunodeficiency virus-inactivating protein cyanovirin-N with high-mannose oligosaccharides on gp120 and other glycoproteins
- Cyanovirin-N, a potent human immunodeficiency virus-inactivating protein, blocks both CD4-dependent and CD4-independent binding of soluble gp120 (sgp120) to target cells, inhibits sCD4-induced binding of sgp120 to cell-associated CXCR4, and dissociates bound sgp120 from target cells
- Analysis of the interaction between the HIV-inactivating protein cyanovirin-N and soluble forms of the envelope glycoproteins gp120 and gp41
- Development of a cyanovirin-N-HIV-1 gp120 binding assay for high throughput screening of natural product extracts by time-resolved fluorescence
- Properties of cyanovirin-N (CV-N): inactivation of HIV-1 by sessile cyanovirin-N (sCV-N)
- Multiple antiviral activities of cyanovirin-N: blocking of human immunodeficiency virus type 1 gp120 interaction with CD4 and coreceptor and inhibition of diverse enveloped viruses
- Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swapping
- Cyanovirin-N binds to gp120 to interfere with CD4-dependent human immunodeficiency virus type 1 virion binding, fusion, and infectivity but does not affect the CD4 binding site on gp120 or soluble CD4-induced conformational changes in gp120
- The HIV-inactivating protein, cyanovirin-N, does not block gp120-mediated virus-to-cell binding
- Solution structure of cyanovirin-N, a potent HIV-inactivating protein
- Recombinant production of cyanovirin-N, a potent human immunodeficiency virus-inactivating protein derived from a cultured cyanobacterium
- Construction and enhanced cytotoxicity of a [cyanovirin-N]-[Pseudomonas exotoxin] conjugate against human immunodeficiency virus-infected cells
- Analysis of sequence requirements for biological activity of cyanovirin-N, a potent HIV (human immunodeficiency virus)-inactivating protein
- Isolation, primary sequence determination, and disulfide bond structure of cyanovirin-N, an anti-HIV (human immunodeficiency virus) protein from the cyanobacterium Nostoc ellipsosporum
- Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development
Immune System / Immunology
COVID-19 / SARS-CoV-2
- Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein
- Cyanometabolites: molecules with immense antiviral potential
- Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2
- Engineering recombinantly expressed lectin-based antiviral agents
- Engineering Antiviral Agents via Surface Plasmon Resonance
- Discovery of a Natural Product with Potent Efficacy Against SARS-CoV-2 by Drug Screening
- Structural Insight into the Binding of Cyanovirin-N with the Spike Glycoprotein, M(pro) and PL(pro) of SARS-CoV-2: Protein-Protein Interactions, Dynamics Simulations and Free Energy Calculations
- Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications
- Antiviral Cyanometabolites-A Review
Chemistry Data
Open Chemistry Data
Additional Research:
Antioxidant
Anti-inflammatory
Anticancer
Found in Formulas
Reported Therapeutic Roles
- Antiviral
- Microbiocide
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